A double from Harry Kane was not enough to earn three points at Newcastle last week, as a late Joe Willock equaliser earned the Magpies a 2-2 draw.
It was a frustrating return to club football for Spurs, but it was the opposite for United who defeated Brighton 2-1.
Ole Gunnar Solskjaer’s side followed up that win with a 2-0 triumph over Granada in the Europa League on Thursday night.
In one of the key battles in this game, England teammates Harry Maguire and Kane will be up against each other, with the United defender eager to build on momentum from the Brighton win: “It’s a great game to be involved in. Really pleased that we’re going into it on the back of three points against Brighton (last weekend). Take that little bit of momentum into the game.
“It’s always a tough game after the international break and I always feel like the points are the big thing – you don’t really look at the performance. Spurs is going to be a big one. It’s one that we’re looking forward to. We had a bad result against them at Old Trafford this season, so we’ll be looking to get one back.”
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at the Tottenham Hotspur Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 4pm GMT.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription. We may earn commission from some of the links in this article, but we never allow this to influence our content.
What is the team news?
Tottenham will be without Ben Davies and Matt Doherty due to ankle and muscle injuries respectively, but Spurs have no other injury issues.
Ole Gunnar Solskjaer is hopeful that Marcus Rashford will be available after being substituted on Thursday due to an ankle issue. Luke Shaw also picked up a knock and was withdrawn in the Europa League but he could also play. Anthony Martial, Phil Jones and Eric Bailly are out.
Tottenham: Lloris, Aurier, Sanchez, Alderweireld, Reguilon, Lucas, Ndombele, Hojbjerg, Bale, Kane, Son
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Pogba, Greenwood, Fernandes, Rashford, Cavani
Manchester United: 7/5
This is a tight one to call. United are in the ascendency, but both sides have the potential to rip the other apart. 2-2.